Anti-human CD8 Cd8a Monoclonal Antibody FITC Conjugated, Flow Validated

• Background:

  The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It is mapped to 2p11.2. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene also encodes the CD8 alpha chain isoforms.

• Description:

  Boster Bio Anti-human CD8 Cd8a Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC02236-FITC) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

• Synonyms:

  T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; CD8a; Cd8a; Lyt-2, Lyt2

• Gene Name:

  Cd8a

• UniProt:

  P01732

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human peripheral blood T lymphocytes

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: OKT8

• Conjugation:

  FITC

• Applications:

  Flow Cytometry

• Field of Research:

  Adaptive Immunity, Immunology, T Cells

• Purification:

  Protein A purified

• Sensitivity:

  5ul per sample

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Dilution:

  User needs to optimize the dilution ratio for this antibody.

• Form:

  Liquid

• Function:

  Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

• Molecular Weight:

  27456 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 2-8°C. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG2a, k

• Other Gene Names:

  T-cell surface glycoprotein CD8 alpha chain

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  T-cell surface glycoprotein CD8 alpha chain