B-NGF beta Nerve Growth Factor Human Recombinant Protein, HEK

• Description:

  BNGF Human Recombinant produced in HEK293 is a noncovalently disulfide linked homodimer, glycosylated, polypeptide chain (Ser122-Arg239) containing 2 identical 118 amino acids and having a molecular mass of 26.5 kDa.

• Synonyms:

  Beta Polypeptide; NGF; NGFB; HSAN5; Beta-NGF; MGC161426; MGC161428

• Gene Name:

  NGF

• UniProt:

  P01138

• Reactivity:

  Human

• Source:

  HEK293

• Purification:

  Greater than 97% as obsereved by SDS-PAGE.

• Bioactivity:

  50

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  It is recommended to reconstitute the lyophilized b-NGF in sterile distilled pyrogen free water at a concentration of 0.25mg/ml.

• Function:

  Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized b-NGF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution b-NGF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Other Gene Names:

  Beta-nerve growth factor

• Subcellular Location:

  Secreted.