IL17RB Interleukin-17 Receptor Beta Mouse Recombinant Protein

• Background:

  Il17rb; Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1; IL-17 receptor B; IL-17RB; Interleukin-17 receptor B

• Description:

  IL17RB produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 511 amino acids (18-286 a.a.) and having a molecular mass of 57.1kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa) . IL17RB is expressed with an 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

• Synonyms:

  Il17rb; Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1; IL-17 receptor B; IL-17RB; Interleukin-17 receptor B

• Gene Name:

  RSPO1

• UniProt:

  Q9Z132

• Conjugation:

  IL17RB protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
  

• Tissue Specificity:

  Expressed in the dorsal part of the neural tube on 10 and 12 dpc, especially in the boundary region between roof plate and neuroepithelium. This expression is enhanced in the rostral part. Also expressed in other tissues such as truncal region neighboring forelimbs and mesenchymal tissues around the nasal cavity.

• Source:

  Baculovirus, Sf9 cells

• Sequence:

  [object Object]

• Purification:

  Greater than 90.0% as determined by SDS-PAGE.

• Bioactivity:

  Baculovirus, Sf9 cells

• Form:

  Sterile Filtered colorless solution.

• Function:

  Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646) . Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity) . Regulates Wnt signaling by antagonizing DKK1/KREM1- mediated internalization of LRP6 through an interaction with KREM1 (By similarity) .

• Molecular Weight:

  https://www.bosterbio.com/media/catalog/product/r/e/recombinant-protein-thumbnail_1.png

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Avoid multiple freeze-thaw cycles.

• Fragment:

  Sterile Filtered colorless solution.

• Other Gene Names:

  R-spondin-1

• Subcellular Location:

  Secreted