GDNF Glial-Derived Neurotrophic Factor Mouse Recombinant Protein

• Description:

  Glial derived Neurotrophic Factor Mouse Recombinant produced in E. coli is a non-glycosylated homodimer containing 2 x 135 amino acids and having a total molecular mass of 30.2kDa. GDNF is purified by proprietary chromatographic techniques.

• Synonyms:

  ATF1; ATF2; HFB1-GDNF; GDNF

• Gene Name:

  GDNF

• UniProt:

  P48540

• Reactivity:

  Mouse

• Tissue Specificity:

  Expressed in both the central nervous system (CNS) and in non-CNS tissues. Expressed in a highly dynamic pattern in the anterior neuroectoderm during the early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5, expression begins in mesenchymal tissues of several organs including the digestive tract, kidney, testis, frontonasal mass, tooth primordium, tongue, mandible, whisker follicles, ear, eye, limb bud and in distinct regions of the brain. Also expressed in the heart, ileum, liver and muscle.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 98.0% as determined by analysis by SDS-PAGE.

• Bioactivity:

  50

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  It is recommended to reconstitute the lyophilized Glial Derived Neurotrophic Factor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

• Function:

  Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized Glial-derived Neurotrophic Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDNF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Please prevent freeze-thaw cycles.

• Other Gene Names:

  Glial cell line-derived neurotrophic factor

• Subcellular Location:

  Secreted.