BPI Bactericidal/Permeability-Increasing Protein Human

• Description:

  The native protein BPI is isolated from human buffy coats and has a molecular mass of 53kDa.

• Synonyms:

  Bactericidal/permeability-increasing protein; CAP 57

• Gene Name:

  BPI

• UniProt:

  P17213

• Reactivity:

  Human

• Tissue Specificity:

  Restricted to cells of the myeloid series.

• Purification:

  Greater than 70% as determined by SDS-PAGE and capillary electrophoresis.

• Function:

  The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

• Other Gene Names:

  Bactericidal permeability-increasing protein

• Subcellular Location:

  Secreted