Anti-KMT5A / SETD8 / Pr-SET7 Monoclonal Antibody, Carrier-free

• Description:

  Boster Bio Anti-KMT5A / SETD8 / Pr-SET7 Monoclonal Antibody catalog # M05349. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Kinesin-like protein KIFC1;Kinesin-like protein 2;Kinesin-related protein HSET;KIFC1;HSET, KNSL2;

• Gene Name:

  Kinesin-like protein KIFC1

• UniProt:

  Q9NQR1

• Host:

  Rabbit

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  A synthesized peptide derived from human KMT5A / SETD8 / Pr-SET7 Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) . H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.

• Clonality:

  Monoclonal

• Clone:

  Clone: ADHO-11

• Tissue Specificity:

  Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung.

• Applications:

  WB,Flow Cytometry

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Minus end-ed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). .

• Components:

  Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

• Storage Conditions:

  Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  73748 MW

• Observed Molecular Weight:

  72 kDa

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:1000-1:5000
  FC 1:100

• Subcellular Location:

  Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Early endosome . Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. .

• Protein Name:

  T-cell surface glycoprotein CD3 zeta chain