Anti-Phospho-Tau (S396) MAPT Rabbit Monoclonal Antibody, Carrier-free

• Description:

  Boster Bio Anti-Phospho-Tau (S396) MAPT Rabbit Monoclonal Antibody catalog # P00097-2. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

• Phospho Site:

  S396

• Synonyms:

  Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;MAPT;MAPTL, MTBT1, TAU;

• Gene Name:

  Microtubule-associated protein tau

• UniProt:

  P10636

• Host:

  Rabbit

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  A synthesized peptide derived from human Phospho-Tau (S396)

• Clonality:

  Monoclonal

• Clone:

  Clone: FCO-13

• Tissue Specificity:

  Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

• Applications:

  WB,IHC

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Function:

  Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. .

• Components:

  Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

• Storage Conditions:

  Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  78928 MW

• Observed Molecular Weight:

  50-70 kDa

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:10000-1:20000
  IHC 1:100-1:500

• Subcellular Location:

  Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.