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AA147

CAT: 0804-HY-124293-08Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124293-08Size:500 mg
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Description
AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[1][2][3][4].
CAS Number
393121-74-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATF6; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aa147.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2
Molecular Formula
C16H17NO2
Molecular Weight
255.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.|[2]Rosarda JD, et al. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16 (12) :2852-2863. |[3]Kubra KT, et al. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Aug 4;99:110432. |[4]D'Amico D, et al. Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathol Appl Neurobiol. 2022 Aug;48 (5) :e12816.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
CAS Number393121-74-9
PubChem CID882909
IUPAC NameN-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
Molecular FormulaC16H17NO2
Molecular Weight255.31
XLogP3.3
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count19
Formal Charge0
Complexity286
SMILES
CC1=CC(=C(C=C1)O)NC(=O)CCC2=CC=CC=C2
InChI
InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19)
InChIKey
AWHLTHOHBAGPMY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
CAS: 393121-74-9
CID: 882909
Formula: C16H17NO2
MW: 255.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight255.31
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass255.125928785
Monoisotopic Mass255.125928785
Topological Polar Surface Area49.3 Ų
Heavy Atom Count19
Formal Charge0
Complexity286
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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