AA147

• Description:

  AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ATF6; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aa147.html

• Purity:

  99.81

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2

• Molecular Formula:

  C16H17NO2

• Molecular Weight:

  255.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.|[2]Rosarda JD, et al. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16 (12) :2852-2863. |[3]Kubra KT, et al. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Aug 4;99:110432. |[4]D'Amico D, et al. Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathol Appl Neurobiol. 2022 Aug;48 (5) :e12816.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [393121-74-9]