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AA147

CAT: 0804-HY-124293-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124293-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[1][2][3][4].
CAS Number
393121-74-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATF6; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aa147.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2
Molecular Formula
C16H17NO2
Molecular Weight
255.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.|[2]Rosarda JD, et al. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16 (12) :2852-2863. |[3]Kubra KT, et al. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Aug 4;99:110432. |[4]D'Amico D, et al. Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathol Appl Neurobiol. 2022 Aug;48 (5) :e12816.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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