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SMO-IN-4

CAT: 0804-HY-153499Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153499Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM) . SMO-IN-4 has antitumor activity[1].
CAS Number
1567963-99-8
UNSPSC
12352005
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smo-in-4.html
Solubility
10 mM in DMSO
Smiles
ClC1=CN=C(N2CC3=CN=C(N4CCC(CC4)O)N=C3CC2)C=C1C5=C(C)C=C(C)C=N5
Molecular Formula
C24H27ClN6O
Molecular Weight
450.96
References & Citations
[1]Lu W, et al. Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity. ACS Chem Neurosci. 2017 Sep 20;8 (9) :1980-1994.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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