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S26A5 rabbit pAb

CAT: 0855-ES13250-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13250-01Size:50 µL
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Background
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Description
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
UniProt
P58743
Swiss Prot
P58743
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human S26A5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:100-500
Molecular Weight
81kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
81kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Lateral wall of outer hair cells. .
Other Product Names
Prestin (Solute carrier family 26 member 5)
Gene ID (Human)
375611

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