Anti-Cd6 Antibody (Biotine Conjugate)

• Background:

  CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene. This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis. Multiple transcript variants encoding different isoforms have been found for this gene.

• Description:

  Boster Bio Anti-Cd6 Antibody Picoband® catalog # A03913-2. Tested in ELISA, IHC applications. This antibody reacts with Rat.

• Synonyms:

  Fructose-bisphosphate aldolase B; Liver-type aldolase; ALDOB; ALDB

• Gene Name:

  aldolase, fructose-bisphosphate B

• UniProt:

  Q812A4

• Host:

  Rabbit

• Reactivity:

  Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived rat Cd6 recombinant protein (Position: S52-Q395).

• Clonality:

  Polyclonal

• Tissue Specificity:

  Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.

• Applications:

  IHC,ELISA

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. ly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in ing the differentiation of retinal progenitors towards horizontal and amacrine fates.

• Storage Conditions:

  At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Rat
  ELISA, 0.1-0.5 μg/ml, Rat
  

• Subcellular Location:

  Nucleus. Cytoplasm.