Anti-CD6 Antibody

• Description:

  Boster Bio Anti-CD6 Antibody catalog # A03913-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

• Synonyms:

  T-cell differentiation antigen CD6; T12; TP120; CD6; Soluble CD6; CD6;

• Gene Name:

  CD6

• UniProt:

  P30203

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the Internal region of human CD6. AA range:361-410

• Clonality:

  Polyclonal

• Tissue Specificity:

  Detected on thymocytes (PubMed:15294938) . Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806) . Detected on natural killer (NK) cells (PubMed:16352806) . Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777) . Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954) . Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

• Applications:

  WB, IHC, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089) . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089) . Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752) . Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806) . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777) . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777) . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777) .

• Molecular Weight:

  71801 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  T-cell differentiation antigen CD6

• Subcellular Location:

  Cell membrane

• Protein Name:

  T-cell differentiation antigen CD6