Anti-Desmoglein 3/DSG3 Antibody Picoband®

• Background:

  Desmoglein3 is also known as PVA (Pemphigus Vulgaris Antigen) . Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens 2 different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA, or desmoglein-3) in the case of PV and desmoglein I in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.

• Description:

  Boster Bio Anti-Desmoglein 3/DSG3 Antibody catalog # PA1567. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Desmoglein-3;130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6; DSG3; CDHF6

• Gene Name:

  Desmoglein-3

• UniProt:

  P32926

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 3.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Epidermis, tongue, tonsil, esophagus and carcinomas.

• Applications:

  WB

• Field of Research:

  Cadherins, Cell Adhesion, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.1-0.5μg/ml, Human
  

• Other Gene Names:

  DSG3

• Subcellular Location:

  Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome .

• Sequence Similarities:

  Belongs to the SCF family.

• Protein Name:

  Desmoglein-3