Desmoglein 3 Antibody / DSG3

• Description:

  Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

• UniProt:

  P32926

• Host:

  Mouse

• Immunogen:

  A recombinant human partial protein (amino acids 379-491) was used as the immunogen for the Desmoglein 3 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Store the Desmoglein 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This Desmoglein 3 antibody is available for research use only.

• CAS Number:

  9007-83-4