GSK598809

CAT: 0804-HY-19654-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19654-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9.

CAS Number

863680-45-9

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GSK598809.html

Concentration

10mM

Purity

99.74

Solubility

1M HCl : 28.57 mg/mL (ultrasonic; adjust pH to 2 with HCl) |DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CC1=C(C2=NN=C(SCCCN3CC4(C5=CC=C(C(F)(F)F)C=C5F)CC4C3)N2C)OC=N1

Molecular Formula

C22H23F4N5OS

Molecular Weight

481.51

References & Citations

[1]Appel NM, et al. Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs. J Pharmacol Exp Ther. 2015 Sep;354 (3) :484-92.|[2]Micheli F, et al. 1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D (3) receptor antagonists. J Med Chem. 2010 Jan 14;53 (1) :374-91.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

D3 Receptor

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GTR19211761-01	(-) -GSK598809 hydrochloride
A13695-100	GSK598809 100mg
A13695-50	GSK598809 50mg
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GSK598809

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