Anti-Integrin beta ITGB7 Antibody

• Description:

  Boster Bio Anti-Integrin beta ITGB7 Antibody catalog # A05433. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Integrin beta-7; Gut homing receptor beta subunit; ITGB7;

• Gene Name:

  ITGB7

• UniProt:

  P26010

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from human Integrin β7. at AA range: 671-720

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in a variety of leukocyte lines.

• Applications:

  WB, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) . Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

• Molecular Weight:

  86903 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Integrin beta-7

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Integrin beta-7