Anti-Integrin Beta 4 ITGB4 Antibody

• Description:

  Boster Bio Anti-Integrin Beta 4 ITGB4 Antibody catalog # A01015. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Integrin beta-4; GP150; CD104; ITGB4;

• Gene Name:

  ITGB4

• UniProt:

  P16144

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein

• Clonality:

  Polyclonal

• Tissue Specificity:

  Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

• Applications:

  WB, IHC

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) . ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464) .

• Molecular Weight:

  202167 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Integrin beta-4

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.

• Protein Name:

  Integrin beta-4