Anti-Phospho-Ron (S1394) MST1R Antibody

• Description:

  Boster Bio Anti-Phospho-Ron (S1394) MST1R Antibody catalog # A01532S1394-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Macrophage-stimulating protein receptor; MSP receptor;2.7.10.1; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MST1R; PTK8, RON;

• Gene Name:

  MST1R

• UniProt:

  Q04912

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human CD136/RON around the phosphorylation site of Ser1394. AA range:1351-1400

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in colon, skin, lung and bone marrow.

• Applications:

  WB, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

• Molecular Weight:

  152241 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Macrophage-stimulating protein receptor

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Macrophage-stimulating protein receptor