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Ron (phospho-S1394) polyclonal antibody

CAT: 0384-BS4382-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS4382-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis. The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K) /Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival. The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD_antigen; CD136; MST1R; PTK8; RON
Swiss Prot
Q04912
Reactivity
Human
Immunogen
Synthetic phosphopeptide derived from human Ron around the phosphorylation site of Serine 1394
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylated
Molecular Weight
~ 150 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Ron (phospho-S1394) polyclonal antibody detects endogenous levels of Ron protein only when phosphorylated at Ser1394.
Applications Notes
Western blot (WB) analysis of Ron (phospho-S1394) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40µg) Lane2:SK-OVCAR3 whole cell lysate (40µg) Lane3:MCF-7 whole cell lysate (40µg)
Host or Source
Rabbit

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