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Anti-TCHP Antibody

CAT: 0519-A11231Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A11231Size:100 µL
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Description
Boster Bio Anti-TCHP Antibody catalog # A11231. Tested in ELISA, WB applications. This antibody reacts with Human.
Synonyms
Trichoplein keratin filament-binding protein; Protein TCHP; Mitochondrial protein with oncostatic activity; Mitostatin; Tumor suppressor protein; TCHP
Gene Name
TCHP
UniProt
Q9BT92
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level) . Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.
Applications
WB, ELISA
Purification
TCHP antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701) . Is a negative regulator of ciliogenesis (PubMed:25270598) .
Molecular Weight
61072 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Trichoplein keratin filament-binding protein
Subcellular Location
Cytoplasm, cytoskeleton
Protein Name
Trichoplein keratin filament-binding protein

UniProtKB · Q9BT92

Trichoplein keratin filament-binding protein

TCHP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BT92
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TCHP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein TCHP
EC number
—
Processing
—
Secondary accessions
Q8NAG0
Protein keywords

Biological process

ApoptosisCilium biogenesis/degradation

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneMitochondrion

Domain

Coiled coil

PTM

Isopeptide bondUbl conjugation

Technical term

Proteomics identificationReference proteome

Disease

Tumor suppressor

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