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Anti-PTPRB Antibody

CAT: 0519-A05673Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A05673Size:100 µL
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Description
Boster Bio Anti-PTPRB Antibody catalog # A05673. Tested in ELISA, WB applications. This antibody reacts with Human.
Synonyms
Receptor-type tyrosine-protein phosphatase beta; Protein-tyrosine phosphatase beta; R-PTP-beta;3.1.3.48; Vascular endothelial protein tyrosine phosphatase; VE-PTP; PTPRB; PTPB;
Gene Name
PTPRB
UniProt
P23467
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from human protein at AA range: 280-360
Clonality
Polyclonal
Applications
WB, ELISA
Purification
PTPRB antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity) .
Molecular Weight
224301 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Receptor-type tyrosine-protein phosphatase beta
Subcellular Location
Membrane ; Single-pass type I membrane protein .
Protein Name
Receptor-type tyrosine-protein phosphatase beta

UniProtKB · P23467

Receptor-type tyrosine-protein phosphatase beta

PTPRB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23467
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPRB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein-tyrosine phosphatase beta, R-PTP-beta
EC number
3.1.3.48
Processing
Precursor
Secondary accessions
B7ZKS8, B7ZKT0, C9JX87, F5H3G6, Q14D85, Q3MIV7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

PTM

GlycoproteinPhosphoprotein

Molecular function

HydrolaseProtein phosphatase

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

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