Anti-ADP-ribosylation factor 6 ARF6 Antibody

• Background:

  The ADP-ribosylation factor 6 (ARF6) is a member of the ARF family, which is part of the RAS superfamily (1) . The ARF proteins are small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D (2) . The product of this gene is localized to the plasma membrane (3), and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling (4) .

• Description:

  Boster Bio Anti-ADP-ribosylation factor 6 ARF6 Antibody (Catalog # A00927) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  ADP-ribosylation factor 6

• Gene Name:

  ARF6

• UniProt:

  P62330

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  ARF6 antibody is human, mouse and rat reactive.

• Immunogen:

  ARF6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ARF6. The immunogen is located within the last 50 amino acids of ARF6.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitous, with higher levels in heart, substantia nigra, and kidney.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Signal Transduction

• Purification:

  ARF6 antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762) . Required for normal completion of mitotic cytokinesis (By similarity) . Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity) . Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216) . Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity) . Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity) .

• Molecular Weight:

  20082 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  ARF6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  ADP-ribosylation factor 6

• Subcellular Location:

  Cytoplasm, cytosol

• Prediction Reactivity:

  Pig, Chicken

• Protein Name:

  ADP-ribosylation factor 6