Anti-Calcipressin-2 RCAN2 Antibody

• Background:

  Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

• Description:

  Boster Bio Anti-Calcipressin-2 RCAN2 Antibody (Catalog # A11369) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Csp2, MCIP2, ZAKI-4, Dscr1l1, Zaki4, Calcipressin-2, Calcineurin inhibitory protein ZAKI-4

• Gene Name:

  RCAN2

• UniProt:

  Q9JHG2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  RCAN2 antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2. The immunogen is located within amino acids 70 - 120 of RCAN2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Neuroscience

• Purification:

  RCAN2 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

• Molecular Weight:

  22025 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  RCAN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Regulator of calcineurin 2

• Subcellular Location:

  Cytoplasm .

• Prediction Reactivity:

  Bovine

• Protein Name:

  Regulator of calcineurin 2