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Anti-PDCD5 Antibody

CAT: 0519-A02613Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A02613Size:0.1 mg
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Background
Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
Description
Boster Bio Anti-PDCD5 Antibody (Catalog # A02613) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Programmed Cell Death 5, TF-1 Cell Apoptosis-Related Protein 19, TF1 Cell Apoptosis-Related Gene 19, Programmed Cell Death Protein 5, TFAR19 Novel Apoptosis-Related, TFAR19, Protein TFAR19
Gene Name
PDCD5
UniProt
O14737
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
PDCD5 antibody was raised against a 21 amino acid synthetic peptide from near the carboxy terminus of human PDCD5. The immunogen is located within the last 50 amino acids of PDCD5.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta.
Applications
ELISA, WB, ICC, IF
Field of Research
Neuroscience
Purification
PDCD5 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
May function in the process of apoptosis.
Molecular Weight
14285 MW
Shipping Conditions
Available
Storage Conditions
PDCD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Programmed cell death protein 5
Subcellular Location
Cell membrane
Prediction Reactivity
Bovine
Protein Name
Programmed cell death protein 5

UniProtKB · O14737

Programmed cell death protein 5

PDCD5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14737
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DE64, Q53YC9, Q6IB70
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

CytoplasmNucleus

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