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Anti-PDCD4 Antibody

CAT: 0519-A01105-1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A01105-1Size:0.1 mg
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Background
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.
Description
Boster Bio Anti-PDCD4 Antibody (Catalog # A01105-1) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
H731, H731, Programmed cell death protein 4, Neoplastic transformation inhibitor protein
Gene Name
PDCD4
UniProt
Q53EL6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
PDCD4 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human PDCD4. The immunogen is located within the last 50 amino acids of PDCD4.
Clonality
Polyclonal
Tissue Specificity
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Applications
ELISA, WB, IHC-P
Field of Research
Apoptosis, Cancer
Purification
PDCD4 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity) .
Molecular Weight
51735 MW
Shipping Conditions
Available
Storage Conditions
PDCD4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Programmed cell death 4 (neoplastic transformation inhibitor)
Subcellular Location
Nucleus
Prediction Reactivity
Chicken
Protein Name
Programmed cell death 4 (neoplastic transformation inhibitor)

UniProtKB · Q53EL6

Programmed cell death protein 4

PDCD4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q53EL6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RCV4, B5ME91, O15501, Q5VZS6, Q6PJI5, Q8TAR5, Q99834
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

CytoplasmNucleus

Domain

Repeat

Molecular function

RNA-binding

Disease

Tumor suppressor

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