Anti-C4 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-C4 Rabbit Monoclonal Antibody catalog # M01095-2. Tested in WB, ICC/IF applications. This antibody reacts with Human.

• Synonyms:

  Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD36; SCARB1; CD36L1, CLA1

• Gene Name:

  Scavenger receptor class B member 1

• UniProt:

  P0C0L4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human C4

• Clonality:

  Monoclonal

• Clone:

  Clone: 17C85

• Tissue Specificity:

  Widely expressed.

• Applications:

  WB, ICC, IF

• Field of Research:

  Complement, Immunology, Innate Immunity

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high density lipoproteins (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins (By similarity) . Necessary for selective HDL-cholesterol uptake (PubMed:26965621) . Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate (By similarity) . .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  ICC/IF 1:50-1:200

• Other Gene Names:

  C4A

• Subcellular Location:

  Cell membrane ; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

• Protein Name:

  Glycogen synthase kinase-3 beta (gsk3b)