Anti-C4 Antibody

• Description:

  Boster Bio Anti-C4 Antibody catalog # A01095-2. Tested in WB, ICC/IF, IHC applications. This antibody reacts with Human.

• Synonyms:

  Complement C4-A; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain; C4A; CO4, CPAMD2;

• Gene Name:

  C4A

• UniProt:

  P0C0L4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant protein

• Clonality:

  Polyclonal

• Tissue Specificity:

  Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response.

• Applications:

  WB, ICC, IF, IHC

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.

• Molecular Weight:

  192785 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Complement C4-A

• Subcellular Location:

  Secreted. Cell junction, synapse

• Protein Name:

  Complement C4-A