Tissue plasminogen activator from Human, Recombinant

Tissue plasminogen activator from Human, Recombinant

• Description: Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism.
• CAS Number: 9000-83-3
• Activity: 580,000 I U/mg
• Storage Conditions: -20°C