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Vorbipiprant

CAT: 0804-HY-156649-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156649-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vorbipiprant (CR6086) is an orally active EP4 receptor antagonist with high selectivity for the human EP4 receptor (Ki: 16.6 nM) . Vorbipiprant has immunomodulatory, anti-inflammatory, antitumor, and anti-angiogenic activities. Vorbipiprant can inhibit the expression of multiple pro-inflammatory cytokines and the activation of immune cells, and convert "cold" tumors unresponsive to immune checkpoint inhibitors into "hot" tumors. Vorbipiprant is used in the research of diseases such as rheumatoid arthritis and colon cancer[1][2].
CAS Number
1417742-86-9
Product Name Alternative
CR6086
UNSPSC
12352005
Target
Interleukin Related; MMP; PD-1/PD-L1; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vorbipiprant.html
Purity
99.72
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C2(CC2)NC(C3N(CCC4(C3)CC4)CC5=CC=C(C(F)(F)F)C=C5)=O)C=C1)O
Molecular Formula
C26H27F3N2O3
Molecular Weight
472.50
References & Citations
[1]Caselli G, et al. Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug. Arthritis Res Ther. 2018 Mar 1;20 (1) :39.|[2]Caselli G, et al. Combination of the EP4 antagonist CR6086 and anti-PD-1 monoclonal antibody inhibits tumor growth in a microsatellite stable colorectal cancer in mice. Cancer Research, 2020, 80 (16_Supplement) : 2208-2208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
EP; IL-17; IL-23; IL-6; MMP-9

Alternative Products

CatalogName
T88706-01(R) -Vorbipiprant

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