Recombinant Human/Mouse/Rat GDF-8/Myostatin

• Background:

  Growth/differentiation factor 8 (Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.

• Abbreviation:

  GDF-8; Myostatin

• Synonyms:

  GDF-8; Gdf8; Growth/differentiation factor 8; Mstn; Myostatin

• UniProt:

  O14793

• Accession Number:

  O14793

• Expression System:

  HEK293 Cells

• Tag:

  None

• Sequence:

  Lys262-Ser375

• Field of Research:

  Signal Transduction; Cell biology; Neuroscience; Cancer

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  13.1 kDa

• Observed Molecular Weight:

  12-15 kDa

• Species:

  Human/Mouse/Rat