Recombinant Human ACE2 Protein (mFc Tag)

• Background:

  Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

• Abbreviation:

  ACE2

• Synonyms:

  ACE-Related Carboxypeptidase; ACE2; ACEH; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Homolog; Metalloprotease MPROT15

• UniProt:

  Q9BYF1

• Accession Number:

  Q9BYF1

• Expression System:

  HEK293 Cells

• Tag:

  C-mFc

• Sequence:

  Gln18-Ser740

• Applications:

  ELISA

• Field of Research:

  Cell biology; Cardiovascular

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Immobilized 2019-nCoV S1 Protein-Fc (Cat#PKSR030480) at 10μg/ml (100 μl/well) can bind Human ACE-2-mFc (Cat#PKSR030494) . The ED50 of Recombinant Human ACE-2-mFc (Cat#PKSR030494) is 0.58 ug/ml.

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  110 kDa

• Observed Molecular Weight:

  110-140 kDa

• Formulation:

  2

• Species:

  Human