Recombinant Human ACE2 Protein (His Tag)

Recombinant Human ACE2 Protein (His Tag)

• Background: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
• Abbreviation: ACE2
• Synonyms: ACE-Related Carboxypeptidase, ACE2, ACEH, Angiotensin-Converting Enzyme 2, Angiotensin-Converting Enzyme Homolog, Metalloprotease MPROT15
• UniProt: Q9BYF1
• Accession Number: Q9BYF1
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Gln18-Ser740
• Applications: BLI
• Field of Research: Cell biology;Cardiovascular
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Loaded 2019-nCoV S Protein RBD-mFc on AMC Biosensor, can bind Human ACE-2-His with an affinity constant of 2.06 nM as determined in BLI assay.
• Reconstitution: Not Applicable
• Molecular Weight: 103 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.