Login

Recombinant Mouse Siglec-E (C-Fc)

CAT:
763-PKSM041446-02
Size:
10 µg
Price:
Ask
For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Recombinant Mouse Siglec-E (C-Fc) - image 1
Recombinant Mouse Siglec-E (C-Fc) - image 2
Thumbnail 1
Thumbnail 2

Recombinant Mouse Siglec-E (C-Fc)

  • Background: Siglecs are sialic acid specific I-type lectins that are characterized by an extracellular domain (ECD) with an N-terminal Ig-like V-set domain followed by varying numbers of Ig-like C2-set domains. Mouse Siglec-E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 - 85 kDa member of the CD33-related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec-9 is the most likely human ortholog of mouse Siglec-E. Siglec-E is expressed as a heavily N-glycosylated disulfide-linked homodimer and shows binding preference for disialic acids in the alpha 2-8 linkage. Siglec-E is up-regulated and additionally phosphorylated following cellular stimulation by a variety of TLR agonists. Siglec-E signaling negatively regulates the LPS-induced production of TNF- alpha and IL-6 by macrophages. Its up-regulation in macrophages parallels the development of endotoxin tolerance. Siglec-E recognition of sialylated determinants on virulent T. cruzi contributes to the suppression of dendritic cell IL-12 p40 production.
  • Abbreviation: Siglec-E
  • Synonyms: Sialic Acid Binding Ig-like Lectin E, Siglec-E, SiglecE
  • CAS Number: 9000-83-3
  • UniProt: Q6PJ50
  • Accession Number: Q6PJ50
  • Host: HEK293 Cells
  • Origin Species: Mouse
  • Tag: C-Fc
  • Sequence: Gln20-Phe355
  • Purity: > 95 % as determined by reducing SDS-PAGE.
  • Bioactivity: Not validated for activity
  • Reconstitution: Please refer to the printed manual for detailed information.
  • Molecular Weight: 85-95 kDa
  • Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
  • Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

MSDS