Recombinant Mouse IL-11RA (C-6His)

Recombinant Mouse IL-11RA (C-6His)

• Background: Interleukin 11 receptor alpha (IL 11 R alpha, IL 11 R alpha 1) originally designated NR1 in mouse, is a 49 kDa type I transmembrane protein that is a member of the gp130 subfamily of the hematopoietic cytokine receptor family. IL-11 R alpha first binds IL 11 with low affinity, then forms a high affinity receptor when complexed with gp130 homodimers. IL 11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL 11 signaling may be a factor in inflammation-associated gastrointestinal cancer development. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.
• Abbreviation: IL-11RA
• Synonyms: Etl, IL-11 R alpha, IL11R alpha, IL-11Ra, Il11ra2, NR1, Etl2, Il11ra, Il11ra1, AI314697, GP130, RP23-167I12.2
• CAS Number: 9000-83-3
• UniProt: Q64385
• Accession Number: Q64385
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Ser24-Gln367
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 40-55 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.