Recombinant Mouse CXCL2/MIP-2 Protein

Recombinant Mouse CXCL2/MIP-2 Protein

• Background: C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
• Abbreviation: CXCL2;MIP-2
• Synonyms: C-X-C motif chemokine 2, GRO beta, GRO2, GROB, Gro-beta, Growth-regulated protein beta, MGSA-b, MGSA-beta, MIP-2, MIP2-alpha, MIP2A, Macrophage Inflammatory Protein-2-alpha, SCYB2., chemokine ligand 2, cxcl2, melanoma growth stimulatory activity beta
• CAS Number: 9000-83-3
• UniProt: P10889
• Accession Number: P10889
• Host: E. coli
• Origin Species: Mouse
• Tag: N-His
• Sequence: Ala28-Asn100
• Applications: Cell culture
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2.The ED₅₀ for this effect is <0.5 ng/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 11 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.