Recombinant Mouse Semaphorin-4D/SEMA4D Protein (His Tag)

Recombinant Mouse Semaphorin-4D/SEMA4D Protein (His Tag)

• Background: Semaphorin 4D (SEMA4D or CD1) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. VEGF and SEMA4D had a positive correlation with the malignant degree of ovarian cancer, and SEMA4D can serve as an independent prognostic factor. SEMA4D was the first semaphorin described to have immune functions and serves important roles in T cell priming, antibody production, and cell-to-cell adhesion. Proteolytic cleavage of SEMA4D from the cell surface gives rise to a soluble fragment of SEMA4D (sSEMA4D). Similar to the transmembranal form, sSEMA4D is thought to have immunoregulatory properties.
• Synonyms: CD100, M-Sema G, SEMA4D, Sema J, Semacl2, Semaj, Semaphorin-4D, Semaphorin-C-like 2, Semaphorin-J, coll-4
• CAS Number: 9000-83-3
• UniProt: O09126
• Accession Number: NP_038688.2
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Met 1-Arg 733
• Applications: ELISA
• Purity: > 96 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured by its ability to bind human SEMA4A in a functional ELISA.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 100-110 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.