Recombinant Human CD59 (C-6His)

Recombinant Human CD59 (C-6His)

• Background: CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
• Abbreviation: CD59
• Synonyms: 16.3A5, 1F5, 1F5 antigen, 20 kDa homologous restriction factor, CD59, CD59 antigen, CD59 glycoprotein, EL32, FLJ38134, FLJ92039, G344, HRF-20, HRF20, MAC-IP, MACIF, MIC11, MIC11MSK21, MIN1, MIN2, MIN3, MIRL, p18-20
• CAS Number: 9000-83-3
• UniProt: P13987
• Accession Number: P13987
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Leu26-Asn102
• Field of Research: Signal Transduction;Cardiovascular;immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 15-20 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.