Recombinant Human PVRIG (C-mFc)
CAT:
763-PKSH034019-01
Size:
50 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human PVRIG (C-mFc)
- Background: Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
- Abbreviation: PVRIG
- Synonyms: C7orf15, C7orf15MGC138295, CD112R, MGC104322, MGC138297, MGC2463, PVRIG, transmembrane protein PVRIG
- CAS Number: 9000-83-3
- UniProt: Q6DKI7
- Accession Number: Q6DKI7
- Host: HEK293 Cells
- Origin Species: Human
- Tag: C-mFc
- Sequence: Thr41-Asp171
- Applications: BLI
- Field of Research: Cell biology
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Loaded Biotinylated Human Nectin-2-His on His Biosensor, can bind Human PVRIG with an affinity constant of 84.68 nM as determined in BLI assay.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 45-55 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.