Recombinant Human TRAIL R1 / DR4 / TNFRSF10A (C-6His）

Recombinant Human TRAIL R1 / DR4 / TNFRSF10A (C-6His）

• Background: Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1/TRAIL), and thus transduces cell death signal and induces cell apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.
• Abbreviation: TRAIL R1;DR4;TNFRSF10A
• Synonyms: APO2, CD261, CD261 antigen, DR4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL-R1, TRAILR1, cytotoxic TRAIL receptor
• CAS Number: 9000-83-3
• UniProt: O00220
• Accession Number: O00220
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Ala24-Asn239
• Field of Research: Cell biology;Cardiovascular;immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 19-30 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.