Recombinant Human TRAIL Protein

Recombinant Human TRAIL Protein

• Background: Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
• Abbreviation: TRAIL
• Synonyms: APO2L, Apo-2 Ligand, Apo-2L, CD253, Protein TRAIL, TNF-Related Apoptosis-Inducing Ligand, TNFSF10, TRAIL, Tumor Necrosis Factor Ligand Superfamily Member 10
• UniProt: P50591
• Accession Number: P50591
• Host: E. coli
• Origin Species: Human
• Tag: C-His
• Sequence: Arg115-Gly281
• Applications: Cell culture
• Field of Research: Cell biology;Cardiovascular;Cancer
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to induce cytotoxicity in L929 cells in the presence of actinomycin D. The ED₅₀ for this effect is 10.4-15.4 ng/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 18 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.