Recombinant Human Signal Transducer CD24/CD24 (C-mFC)

Recombinant Human Signal Transducer CD24/CD24 (C-mFC)

• Background: Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.
• Abbreviation: CD24
• Synonyms: CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen
• CAS Number: 9000-83-3
• UniProt: P25063
• Accession Number: P25063
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-mFc
• Sequence: Ser27-Gly59
• Field of Research: Neuroscience;Cancer;immunology;metabolism;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 40-60 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.