Recombinant Human Interleukin-23/IL-23 (C-Fc)

Recombinant Human Interleukin-23/IL-23 (C-Fc)

• Background: Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
• Abbreviation: Interleukin-23;IL-23
• Synonyms: CLMF p40, IL-12 subunit p40, IL-23p19, NKSF2, SGRF
• CAS Number: 9000-83-3
• UniProt: P29460;Q9NPF7
• Accession Number: P29460&Q9NPF7
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-Fc
• Sequence: Ile23-Ser328&Ala21-Pro189
• Applications: Cell culture
• Field of Research: Microbiology;Cancer;immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells. The ED₅₀ for this effect is 179.42 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 80-110 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.