Recombinant Human CD3 epsilon/CD3E (C-mFC)

Recombinant Human CD3 epsilon/CD3E (C-mFC)

• Background: T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
• Abbreviation: CD3 epsilon;CD3E
• Synonyms: CD3E, CD3e, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T3E
• CAS Number: 9000-83-3
• UniProt: P07766
• Accession Number: P07766
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-mFC
• Sequence: Gln22-Thr48
• Applications: ELISA
• Field of Research: immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Immobilized Anti-Human/Monkey CD3E mAb at 2μg/ml (100 μl/well) can bind Human CD3E-mFc.The ED50 of Human CD3E-mFc is 28.99 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 32-40 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.