Recombinant Human CD27 Ligand/TNFSF7/CD70 (C-mFc)

• Background:

  CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

• Abbreviation:

  TNFSF7; CD70

• Synonyms:

  CD27 ligand; CD27L; CD27LG; CD70; CD70 antigen; TNFSF7; Tumor necrosis factor ligand superfamily member 7

• UniProt:

  P32970

• Accession Number:

  P32970

• Expression System:

  HEK293 Cells

• Tag:

  C-mFc

• Sequence:

  Gln45-Pro193

• Field of Research:

  Cancer; immunology; Stem cells

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  43.0 kDa

• Observed Molecular Weight:

  50-60 kDa

• Species:

  Human