Recombinant Human/Mouse/Rat BDNF Protein
CAT:
763-PKSH033808-02
Size:
20 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human/Mouse/Rat BDNF Protein
- Background: Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF; NT-3 and NT-4; BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor; also known as p75). BDNF promotes the survival; growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
- Abbreviation: BDNF
- Synonyms: Abrineurin, BDNF, Brain-Derived Neurotrophic Factor
- CAS Number: 9000-83-3
- UniProt: P23560
- Accession Number: P23560
- Host: E. coli
- Origin Species: Human, Mouse, Rat
- Tag: C-His
- Sequence: His129-Arg247
- Applications: Cell culture
- Field of Research: Cardiovascular;Neuroscience;metabolism
- Purity: > 98 % as determined by reducing SDS-PAGE.
- Bioactivity: Measure by its ability to induce proliferation in BaF3 cells transfected with TrkB. The ED50 for this effect is <2 ng/mL.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 14 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.