Recombinant Human/Mouse/Rat BDNF Protein

• Background:

  Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF; NT-3 and NT-4; BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor; also known as p75) . BDNF promotes the survival; growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson' s and Alzheimer' s disease.

• Abbreviation:

  BDNF

• Synonyms:

  Abrineurin; BDNF; Brain-Derived Neurotrophic Factor

• UniProt:

  P23560

• Accession Number:

  P23560

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  His129-Arg247

• Applications:

  Cell culture

• Field of Research:

  Cardiovascular; Neuroscience; metabolism

• Endotoxin:

  < 0.1 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 98 % as determined by reducing SDS-PAGE.

• Bioactivity:

  50

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  14.5 kDa

• Observed Molecular Weight:

  14 kDa

• Species:

  Human/Mouse/Rat