Recombinant Human BDNF Protein (with pro peptide)

Recombinant Human BDNF Protein (with pro peptide)

• Background: The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis; whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival; growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects; Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
• Abbreviation: BDNF
• Synonyms: Abrineurin, BDNF, Brain-Derived Neurotrophic Factor
• CAS Number: 9000-83-3
• UniProt: P23560
• Accession Number: P23560
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Ala19-Arg247(R125A,R127A,R128A)
• Field of Research: Cardiovascular;Neuroscience;metabolism
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 28 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.