Recombinant Human/Mouse/Rat Activin A/INHBA Protein

Recombinant Human/Mouse/Rat Activin A/INHBA Protein

• Background: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
• Abbreviation: Activin A;INHBA
• Synonyms: Activin A, INHBA, Inhibin beta A chain
• CAS Number: 9000-83-3
• UniProt: P08476
• Accession Number: P08476
• Host: HEK293 Cells
• Origin Species: Human, Mouse, Rat
• Tag: None
• Sequence: Gly311-Ser426
• Applications: Cell culture
• Field of Research: Signal Transduction;Cancer;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured by its ability to induce SMAD signaling in 293-Activin A Res cells. The ED₅₀ for this effect is 1.3 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 15 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.