Recombinant Human CD28/TP44 Protein (mFc Tag)

Recombinant Human CD28/TP44 Protein (mFc Tag)

• Background: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like)domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals; which are required for T cell activation. CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival; interleukin-2 production; and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands; the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
• Abbreviation: CD28;TP44
• Synonyms: CD28, CD28 antigen, CD28 molecule, T-cell-specific surface glycoprotein CD28, TP44, Tp44
• CAS Number: 9000-83-3
• UniProt: P10747
• Accession Number: P10747
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-mFc
• Sequence: Asn19-Pro152
• Field of Research: immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 40-75 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.