Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated

Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated

• Background: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
• Abbreviation: CD28;TP44
• Synonyms: CD28, CD28 antigen, CD28 molecule, T-cell-specific surface glycoprotein CD28, TP44, Tp44
• CAS Number: 9000-83-3
• UniProt: P10747
• Accession Number: P10747
• Host: HEK293 Cells
• Origin Species: Human, Cynomolyus
• Conjugation: Biotinylated
• Tag: C-Fc-Avi
• Sequence: Asn19-Pro152
• Applications: BLI
• Field of Research: immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Loaded Human B7-1-His on HIS1K Biosensor, can bind Biotinylated Human/Cynomolgus CD28-Fc-Avi with an affinity constant of 9.09 pM as determined in BLI assay.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 60-90 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.